Boosting Mitochondrial Biogenesis With Ginger


January 18th 2020 By: GreenMedInfo Research Group

Researchers discover that ginger, an ancient herbal remedy used for cooking and medicinal purposes, supports the regeneration of cellular mitochondria and may reduce the effects of mitochondrial dysfunction

A study published in the Journal of Food Science found that ginger extract and gingerol, an active compound found in ginger root, both play a similar role in stimulating the AMPK-PCG1PCG1α pathway, which regulates the process of mitochondrial biogenesis.[i]

While further research is warranted, researchers theorize that ginger, considered a potent ancient herbal remedy, could mitigate the effects of aging on mitochondria and significantly reduce or prevent the onset of mitochondrial dysfunction diseases such as diabetesobesitycancer and cardiovascular disorders.

What Is Mitochondrial Biogenesis?

Mitochondria, an organelle found in most cells, perform cellular respiration and metabolic procedures by breaking down nutrients and turning them into energy that the cell uses for various functions. Something like the battery pack of cells, mitochondria make it possible to perform daily activities by deriving energy from carbohydrates and fatty acids.[ii]

Mitochondrial biogenesis is the process used by cells to increase the size of these cellular powerhouses through the growth and division of the existing mitochondria. Impairment of this biogenesis can be linked to the process of aging and multiple diseases such as Type 2 diabetes and Alzheimer’s, so researchers are eager to discover additional methods to regulate biogenesis for prevention and treatment of these diseases.[iii]

Mitochondria: The Key to Slowing the Aging Process?

A byproduct of mitochondrial energy production is the release of free radicals into the body. Although mitochondria produce these free radicals, they are still susceptible to free radical damage.

As your body ages, mitochondria weaken and die, resulting in increased fat storage, decreased skeletal muscle mass and cognitive decline, as well as the onset of other age-related diseases.[iv] Researchers theorize that the proliferation and strengthening of mitochondria (via biogenesis) might be the key to slowing down the aging process and mitigating related illness.[v] Mitochondrial dysfunction disorders include:[vi],[vii]

  • Neurological and muscular degeneration
  • Cardiomyopathies
  • Cancer
  • Aging and related diseases
  • Insulin resistance and Type 2 diabetes mellitus
  • Obesity and obesity-related disorders

It is well known that environmental stressors such as short and medium-term caloric restriction, fasting, exercise and low temperatures (such as cold therapy) all positively impact the process of biogenesis.[viii],[ix],[x] However, researchers are eager to discover additional natural substances that might produce similar results in the proliferation of mitochondria.

Ginger’s Role in Mitochondrial Biogenesis

Researchers studied the impact of ginger extract on several organs and tissues, including skeletal muscles, the heart and liver and found that ginger extract positively influenced several functions related to mitochondrial biogenesis, including:

  • Increased mitochondrial mass
  • Increased mitochondrial DNA (mtDNA) copy number in muscle and liver tissue
  • Increased adenosine triphosphate (ATP) production (ATP is used by cells as energy for metabolic function)
  • Promoted COX4 & OXPHOS protein expression in liver and muscle tissue (a reduction in the enzymatic activity of these genes is linked to Type 2 diabetes and obesity)
  • Induced mitochondrial biogenesis via the AMPK-PGC1α pathway (this pathway induces the process of biogenesis in mitochondria)

Both in vivo and in vitro studies indicated that ginger has the potential to increase mitochondrial biogenesis. Researchers tested the efficacy of both ginger extract and 6-gingerol, a component of ginger root, and found no difference in the results. Thus, they concluded that 6-gingerol may be the active component that stimulates biogenesis.

Other Natural Substances That Stimulate Regenerative Processes

In addition to ginger extract, the following substances have been identified as having therapeutic properties that induce the biogenesis of mitochondria:

For more information on these substances, visit GreenMedInfo’s resourse page on mitochondrial biogenesis. Additional lifestyle intervention methods for supporting cellular regeneration via mitochondrial biogenesis include:

  • Getting quality sleep. Sleep disorders and disturbances are linked to cellular fatigue and poor mitochondrial function.[xi]
  • Consuming omega-3 fatty acids. Mitochondrial dysfunction is linked to high levels of inflammation in the body.[xii] Omega-3 fatty acids are polyunsaturated fats with immunomodulatory activities that help to lower inflammation responses.[xiii] Quality sources of the omega-3 fats eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) include fish oil supplements and wild-caught fish such as salmon, sardines, mackerel and herring.
  • Exercising. Exercise stops mitochondrial aging in its tracks by improving mitochondrial protein quality and increasing mitochondrial content.[xiv],[xv] Studies indicate that high-intensity interval training and activities such as running, walking, swimming and other endurance exercises, as well as resistance training, are beneficial in improving mitochondrial biogenesis.[xvi],[xvii]
  • Supporting detoxification pathways. Consistent exposure to environmental toxins such as pollutants or heavy metals, overuse of drugs and improper nutrition impair mitochondrial function.[xviii],[xix] By eliminating or reducing toxins in your body, cellular toxicity is reduced and mitochondria are better able to perform cellular respiration.
  • Practicing cold exposure. Cold therapy has been shown to increase mitochondrial biogenesis by improving PGC1α protein expression, the protein that regulates and induces the process of biogenesis in cells.[xx],[xxi]

Research Conclusions

Whole-body metabolic function depends on the capacity of mitochondria. By increasing the number and strength of mitochondria through biogenesis, researchers believe that it is possible to significantly reduce or prevent the onset of multiple age-related diseases linked to mitochondrial dysfunction, including diabetes, muscular degeneration, cancer, cognitive disorders, cardiovascular disease and obesity.

Bioactive compounds such as ginger extract or 6-gingerol present an exciting potential therapeutic treatment in the proliferation of mitochondria by activating the AMPK- PGC1α pathway. While more exploration is needed, researchers are eager to continue studying the possible mechanisms of ginger extract in the treatment of mitochondria dysfunction.

THIS DAY IN HISTORY FEBRUARY 18


Encyclopædia Britannica


FEATURED EVENT

True-colour image of Pluto, created from telescopic data collected between 1985 and 1990 during a period of mutual eclipses of Pluto and its moon Charon. Pluto's slightly reddish hue indicates that its surface does not comprise pure ices, though the nature of the material responsible for the colour remains to be determined.

1930 – Pluto discovered by Clyde Tombaugh Using a 13-inch (33-cm) telescope at the Lowell Observatory in Flagstaff, Arizona, Clyde W. Tombaugh, a 24-year-old American with no formal training in astronomy, discovered the dwarf planet Pluto this day in 1930.

Manning, Chelsea; Manning, Bradley

2010 – The Web site WikiLeaks began posting classified U.S. government documents provided by army intelligence analyst Bradley (later Chelsea) Manning; it was believed to be the largest unauthorized release of state secrets in U.S. history.

Davis, Jefferson

1861 – Jefferson Davis was inaugurated as provisional president of the Confederate States of America.

How Great Leaders Control Their Ego


By Lolly Daskal

Everybody has an ego, and a healthy ego is necessary for success in leadership or any field. You need to have faith in yourself and your abilities, and when you’re trying to achieve something difficult, it serves you well to have that voice in your head saying “You’re the one who can make this happen.”

But left unchecked, an ego can be a destructive force. It may keep you from admitting you don’t know something you need to learn, or persuade you not to consider the areas you need to improve upon. Sometimes it takes the form of the fear of looking foolish, which can keep you from speaking up or taking a chance on an opportunity.

Knowing how to manage your ego is important. Here are some of the approaches top leaders use:

They acknowledge and respect their ego. Great leaders understand that the first step in managing their ego is to acknowledge it and respect it. They never try to disingenuously pretend that it doesn’t exist. They respect their ego enough to understand how it serves them, even if it means having to face harsh realities about themselves.

They don’t compare themselves to others. The best leaders understand that big egos come with big expectations, and they resist the constant temptation to measure themselves against others. They compare themselves only to their own ideals and aspirations as they decide what’s most important and focus on getting there.

They never stop learning. The smartest person in the room isn’t the one whose ego is telling them they’re the smartest. It’s the one who knows how much they still have to learn.

They serve a higher purpose. Top leaders know that the best way to control their ego and keep perspective is to remember that the world does not revolve around them. Holding to an attitude of service, in leadership and in life, breaks the pressure we put on ourselves, giving us room to move from self-importance to a sense of genuine purpose. The highest level of achievement is based on passion and service, not hitting a target for personal accomplishment. Living life beyond ourselves in service of others doesn’t just keep our egos in line—it creates more adventure, fulfillment and meaning.

Great leaders understand that controlling their ego is a personal challenge that is critical to success, and it’s something they have to do themselves, every day. It’s the only way to build respect and trust with others.

Lead from within: A big ego can create huge achievement but it can result in huge destruction too. Controlling its power is a skill well worth mastering.

Doll out and Poverty Mentality In Africa


23 killed in stampede as Borno governor distributes food in Niger Republic

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Abdulkareem HarunaGovernor of Borno State, Babagana Zulum [PHOTO: Thecable.ng]Governor of Borno State, Babagana Zulum [PHOTO: Thecable.ng]

At least 23 people have been reported killed in a stampede that occurred as officials of the Borno State Government distributed food items to Nigerian refugees living in Niger Republic.

PREMIUM TIMES reported how the Governor of Borno State, Babagana Zulum, on Sunday, travelled to Diffa, a border community in Niger Republic, where he met over 120,000 Nigerians who fled their homes some years ago.

The 120,000 are among the millions of Nigerians who have been displaced by the Boko Haram insurgency in North-east Nigeria. Majority of the displaced victims reside in other communities and displaced persons camps within Nigeria. Hundreds of thousands of others, however, fled to neighbouring countries like Niger, Chad and Cameroon.

Government sources said Monday’s stampede happened hours after the governor left Niger Republic for Maiduguri.

Mr Zulum had on Sunday supervised the distribution of the food items to about 30,000 refugees before he left with an instruction that the state emergency agencies should continue to distribute the materials.

PREMIUM TIMES gathered that the stampede happened on Monday morning as refugees began to protest the delay in the continuation of the food distribution at the two distribution sites called the MJC Boys and Girls Club in Diffa province.

A Borno official who witnessed the incident said Nigeriens living around the camp stormed the place with the hope of getting some food even though they were not meant to benefit.

“The distribution supervised by Governor Zulum on Sunday was successfully carried out as the entire 30,000 that received the meal token, all got their food and clothing,” the witness said, asking not to be named as he was not authorised to talk to journalists.

READ ALSO: Buhari sends delegation to Katsina over bandits attack

“After the governor had left, the official continued the distribution at a venue called Gidan Wasa, where over 6000 refugees received their shares.

“But things went out of control the second day when some local Nigeriens got wind of the distribution exercise continuing on Monday.

“They rushed down to join the Nigerian refugees at the distribution locations; and in attempts to be the first to get the relief items, a serious stampede ensued.”

The source said of the 23 persons that died, 19 were Nigeriens, while four were Nigerians.

“Most of those that died were aged women and children,” the source said.

The official said the fact that Nigeriens were involved in the stampede “explains the fact that there is serious poverty and hunger in that axis.”

When contacted, the spokesman of the Borno State governor, Isa Gusau, confirmed the development.

He said the government will not be making any official comment on the matter now, “until the governor receives a detail report” of what transpired from the committee handling the distribution of the items to the refugees.

Chinese police put a professor under house arrest, cut his internet, and kicked him off social media after he criticized Xi Jinping over the coronavirus | Business Insider


Truth2Freedom's Blog

Reuters

  • A Chinese professor who wrote a scathing essay criticizing President Xi Jinping’s handling of the novel coronavirus was placed under house arrest and had his internet services cut, The Guardian reported, citing his friends.
  • After returning from his Chinese New Year holiday, Xu Zhangrun was put under house arrest, with several people patrolling the entrance of his home in Beijing.
  • Friends of the professor told The Guardian that Xu’s social media accounts have either been removed or suspended.

A Chinese professor who publicly criticized President Xi Jinping’s handling of the deadly Wuhan coronavirus has been put under house arrest, banned from social media, and denied access to the internet, his friends told The Guardian.

Xu Zhangrun, a law professor at Beijing’s prestigious Tsinghua University, published a scathing attack on the government’s response to the virus outbreak on February 10. You can read an English translation of it on…

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