No fewer than 815 contractors were recently shortlisted by the 0 for hundreds of constituency projects despite failing to meet federal contracting requirements, an ongoing investigation by PREMIUM TIMES has revealed.
In Nigeria, 61 Political Parties Want Buhari’s Niece Amina Zakari Redeployed Out of Election Commission
By checkpointcharley on 11. January 2019 • ( 0 )
At least 61 political parties have kicked against the draft released by the Independent National Electoral Commission (INEC) on election guidelines.
Ikenga Ugochinyere, publicity secretary of the inter-party advisory council, said in a statement that the 61 parties made their displeasure known in a petition submitted to INEC on Friday.
According to Ugochinyere, the parties disagreed with INEC on eight clauses which they said “will ruin the 2019 elections”.
Among the clauses is the simultaneous accreditation and voting processes which INEC introduced for the elections.
“Political parties demand retention of 2011 and 2015 separate accreditation time and separate voting time to help forstall rigging with the presence of voters at the polling unit instead of INEC 2019 simultaneous accreditation and voting,” he said.
“Political parties demand announcement of accreditation figures by 12 noon on election day and recorded in a signed form and given to party agents before voting starts to forstall doctoring of election figures during collation.”
The statement added that the parties demanded end of PVC collection 10 days to election and the disclosure of the total number of PVCs collected based on various polling units.
“Political parties rejects the clauses in the guideline which allows unduly accredited voters to vote especially the clause that allows voters with PVC whose name is not in the register of voters to vote,” it further read.
“Political parties demand transparency in collation and transmission of results with accredited representatives of election observers and political parties monitoring.
“Political parties reject the creation or usage of secret polling units called voting point settlement and demand full list and location of such units.”
The parties also demanded the redeployment of Amina Zakari, a national commissioner at INEC, as head of the collation centre.
They sought her replacement with Okechukwu Ibeanu, federal commissioner in charge of operations, “to ensure credibility and balancing”.
“Parties threaten to pass vote of no confidence on INEC chairman if he goes ahead to release the contentious guideline on Monday without further consultation with Political Parties Chairmen,” the statement read.
Paradigm Shift from Levothyroxine to Combination T3 T4 Thyroid
Wednesday, January 9th 2019 By: Dr. Jeffrey Dach, MD
Millions take synthetic thyroid hormones without realizing a natural, more bioidentical alternative exists.
As regular readers of my work will know, one of the errors in mainstream endocrinology is the dogmatic insistence on T4 mono-therapy only. Only one single medicine, T4 only, may be prescribed to the hypothyroid patient. This is the (generic) Levothyroxine or (brand name) Synthroid, which is the most prescribed drugs in America with123 million prescriptions in 2016.(1) About 7% of the population is hypothyroid and needs treatment. In my opinion, (NDT) natural desiccated thyroid is preferable to T4 monotherapy. As we will see below, NDT is more robust, more effective and safer than T4 only monotherapy with Levothyroxine. Above left image shows chemical structure of T3 and T4. Courtesy of Failing.com
The Wheels of Change are Turning
The wheels of change are turning, as illustrated by Angela M. Leung, MD writing on the “Love-Hate Relationship with T4“. (1) This caught my attention because it represents the beginning of a paradigm shift in mainstream endocrinology.
Subset of Patients are Dissatisfied with T4-Montherapy
With refreshing honesty, Angela M. Leung, MD points out that a subset of patients are dissatisfied with T4 only Monotherapy, and are actively seeking combination T3 and T4 treatment. Reasons cited are
1) persistent hypothyroid symptoms even though the TSH is in the “normal range” and
2) the possibility of a genetic mutation in the patient called a
De-iodinase polymorphism which impairs conversion of T4 to T3 . (1)
Synthetic T3 T4 Combinations
For the “Synthetic Combination” of T3 and T4, Dr. Angela Leung will prescribe both Cytomel (T3) and Levothyroxine (T4) in dosage that replicates the T3:T4 secretion ratio of the human thyroid:
To best replicate the physiologic ratio of T3:T4 production, the separate prescriptions should be about 1:13-1:20 that of T3 to T4.[20]…A typical formula for a patient on 112 µg of synthetic T4 once daily, the new prescription is 5 µg of synthetic T3 twice daily and 100 µg of synthetic T4 daily.” (1)
Some Patients Prefer (NDT) Natural Desiccated Thyroid
In another burst of refreshing honesty, Dr. Angela Leung actually admits that some patients prefer NDT, which dates back to 1891, and was “grandfathered” in 1938 when the FDA was created. Since it was “grandfathered-in”, NDT skipped formal new- drug approval by the FDA. (1)
Left Image Figure 1 Show activity of De-Iodinase Enzyme varies according to anatomic location, Courtesy of Gereben B, McAninch EA et al 2015) (4)
Concern About 4:1 T4:T3 Ratio
NDT which contains T4 and T3 in a 4:1 ratio can be regarded as another combination therapy. Although Dr. Leung will reluctantly prescribe NDT, she will first try to dissuade the patient by disclosing drawbacks. Namely, Dr. Leung will argue NDT is suboptimal because the T4:T3 ratio in NDT is 4:1, while the thyroid secretion ratio ranges from 12:1 to 20:1. Opposing views in support of the 4:1 ratio can be found among prescribers of natural thyroid. Although the thyroid gland T4:T3 secretion ratio is 12:1, only about 20% of serum T3 comes from thyroid secretion, the other 80% comes from peripheral conversion of T4 to T3. This means the final serum levels are closer to the 3:1 or 4:1 range of which is found in NDT. Even though NDT does not replicate thyroid secretion ratio of 12:1, it does replicate the serum ratio of T4 to T3 (3:1 or 4:1), which in my opinion is more important.
Do the Calculation from Your Own Lab Sheet
Average normal Free T3 is 300 pcg/dl
Average normal Free T4 is 1.0 ng/dl= 1000pcg/dl
FreeT4/Free T3 = 1000/300 = 3.3
The serum Free T4:T3 ratio in the average patient is 3.3:1 a value closer to the 4:1 found in NDT. Remember, after the thyroid pill is ingested and absorbed, it goes into the circulating blood stream as Free T3 and Free T4. So, matching the serum T4:T3 ratio is the most logical dosing strategy.
127 Years of Use
In 15 years of clinical practice prescribing NDT to patients and family members the 4:1 ratio in NDT has NEVER been a significant issue, so I would say this is an example of a medical myth, the creation of an “imaginary” objection. Another thing to think about is this: If there were any significant problems with natural desiccated thyroid requiring a black box warning or removal from the marketplace, it would have happened by now. Natural Desiccated thyroid has been in use for over 127 years, representing the SOLE thyroid medication available from 1891 until 1955 (64 years), after which Synthroid entered the marketplace. For any drug, 127 years of use is a very long track record attesting to safety and efficacy.
Reading the Comment Section
To give you an idea of the typical results we see every week prescribing NDT, read one of the comments by CM below Dr. Angela Leung’s article on Medscape:
From: CM, Health Business/Administration
“For over 15 years of treatment for hypothyroidism with various T4 medications, I complained about continuation of hypothyroid symptoms, only to be told that my blood work was just fine. I finally found a doctor that was open to treating with desiccated thyroid medication and it completely changed my life. All of my symptoms have resolved. If patients speak, please listen and be opened minded enough to try a different medication instead of treating the lab values and not the patient. There are many people that have and would benefit from desiccated thyroid.” Comment section for (1)
Notice in the above comment, there is no mention of a problem with the NDT T4:T3 ratio which is 4:1. Left Image Shows Deiodinase activity varies in different cells…Courtesy of Figure 2 from Gereben B, McAninch EA et al 2015) (4)
My First Thyroid Patient
My first thyroid patient 15 years ago was a 70 year old female who had been on Synthroid for 50 years ever since her total thyroidectomy for a “benign cyst” at age 20. An operation, which in retrospect was probably unnecessary. Three weeks after switching her to NDT natural desiccated thyroid, she came back into the office, threw up her hands and said: “I feel so much better. Why hasn’t any other doctor done this for me before?“, I said, “I don’t know, Mom.” My very first thyroid patient was my mother. Over the years, I have found this type of patient result is typical when switching from T4 mono-therapy to natural desiccated thyroid.
Vaccine shot killed famed cancer doctor in mere minutes from “total organ failure” … state-run media desperately tries to cover it up
Dr. Martin Gore, a widely celebrated cancer doctor credited with “saving thousands of lives” died from “total organ failure” just minutes after receiving a vaccine shot yesterday. Dr. Gore was a professor of cancer medicine at the Institute of Cancer Research based in London. He
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